Antimalarial drugs: Mode of action and status of resistance
نویسندگان
چکیده
منابع مشابه
The mode of action of antimalarial endoperoxides.
The mechanism of action of artemisinin appears to involve two steps. In the first step, activation, intra-parasitic iron catalyses the cleavage of the endoperoxide bridge and the generation of free radicals. In the second step, alkylation, the artemisinin-derived free radical forms covalent bonds with parasite proteins.
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Despite the urgent need of a new antimalarial drugs, particularly those against multiresistant falciparum malaria, only a limited number of drugs are now at an advanced stage of preclinical or clinical development. They include artemisinin derivatives, pyronaridine and benflumetol (all originally developed in China), as well as new antifolate combinations, the hydroxynaphoquinone atovaquone whi...
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Malaria is one of the top health problems in Yemen. This study was done to evaluate the availabilit and prescribing of antimalarial drugs in Al-Mukalla city, based on the treatment guidelines of the National Malari Control Programme (NMCP). Chloroquine, quinine and sulfadoxine/pyrimethamine were the most availabl and prescribed antimalarial drugs in all 60 pharmacies (government and private) in...
متن کاملComplex dynamics and stability of resistance to antimalarial drugs.
A succession of antimalarial drugs has been deployed to treat human falciparum malaria but each has, in turn, been nullified by the spread of drug resistance. The consensus view has always been that, once present, resistance will inevitably rapidly increase to 100%. However, recent field evidence has shown this is not inevitable, and that drug resistance may initially spread and then stabilize ...
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A major issue in the control of malaria is the evolution of drug resistance. Ecological theory has demonstrated that pathogen superinfection and the resulting within-host competition influences the evolution of specific traits. Individuals infected with Plasmodium falciparum are consistently infected by multiple parasites; however, while this probably alters the dynamics of resistance evolution...
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ژورنال
عنوان ژورنال: African Journal of Pharmacy and Pharmacology
سال: 2013
ISSN: 1996-0816
DOI: 10.5897/ajppx12.015